Jeffrey E Wong, MD, FACS

Historical Perspective

PSA is an endogenous serine protease and a member of the human kallikrein gene family identified in 1970. It is a 33kd protein produced and secreted primarily by the prostatic epithelium and epithelial lining of the periurethral gland. When secreted during ejaculation, PSA liquefies the seminal coagulum.

Factors Influencing PSA Measurement

Molecular Forms of PSA

The ProstAssure Index

Age Specific PSA Reference Ranges

PSA Velocity

PSA Density

Monitoring After Radical Prostatectomy